How to Treat Female Anti-Sperm Antibodies?

Female anti-sperm antibodies should first avoid antigen stimulation. Commonly used methods include using a condom for local isolation, interrupting intercourse, or ejaculating outside the body for 6 months to avoid contact between sperm and the female reproductive tract, which can stimulate the continuous production of anti-sperm antibodies in the female body. If anti-sperm antibodies persist, they can be used in combination with other treatment methods. Immunosuppressive agents can also be used, including local therapy, low-dose continuous therapy, and high-dose intermittent dosing. Anti-sperm antibodies are complex pathological products that can affect both men and women, and their exact causes are not fully understood. Male sperm and seminal fluid are specific antigens for women, and when they come into contact with the blood, both men and women can cause immune reactions, produce corresponding antibodies, and block sperm from combining with eggs, leading to infertility. Sperm is obviously a foreign object for women. Normally, women do not produce anti-sperm antibodies, but in some cases, due to inflammation and damage in the female reproductive tract, antibodies may also be produced in female serum and cervical mucus. The presence of these antibodies can hinder sperm from penetrating the cervical mucus and fertilization. If cervical mucus is taken from these women after intercourse for observation, it will be found that the number of active sperm is lower than normal. Some scholars compared the presence of anti-sperm antibodies in the bodily fluids of prostitutes and unmarried women and found that the positive rate among prostitutes was 73%, while it was only 20% among unmarried women. Therefore, the possibility of pregnancy for prostitutes is much lower than for other women.