"What Are the Differences Between Gout and Rheumatoid Arthritis?"

Differences Between Gout and Rheumatoid Arthritis

The distinction between gout and rheumatoid arthritis lies primarily in etiology, clinical manifestations, laboratory tests, and treatment. It is recommended that patients seek medical attention promptly for a definitive diagnosis and targeted therapy.

1. Etiology

Gout is a metabolic disorder caused by excessive production or reduced excretion of uric acid in the body, leading to elevated blood uric acid levels. In contrast, rheumatoid arthritis (RA) is an autoimmune disease associated with genetic and environmental factors.

2. Clinical Manifestations

Gout typically manifests as acute onset of redness, swelling, heat, and pain in joints, often affecting a single joint such as the dorsum of the foot or ankle. Conversely, RA can affect multiple joints, including small joints of the hands and wrist joints, with a symmetrical distribution.

3. Laboratory Tests

During acute gout attacks, blood uric acid levels are significantly elevated, generally exceeding 480μmol/L. A positive rheumatoid factor test indicates a higher likelihood of RA.

4. Treatment

Gout patients are prescribed non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac sodium sustained-release tablets, accompanied by uric acid-lowering medications like benzbromarone tablets. RA patients, on the other hand, are prescribed NSAIDs like celecoxib capsules. In severe cases, glucocorticoids like prednisone acetate tablets may be prescribed under medical supervision. It is crucial to maintain a light diet, avoiding high-purine foods like animal viscera and seafood, while ensuring adequate rest and sleep to prevent prolonged sleep deprivation.