Can taking digestive medication cause diarrhea and blood in stool?

Whether Diarrhea from Digestive Medication Causes Hematochezia: A Case-by-Case Analysis

Whether diarrhea caused by digestive medications leads to hematochezia (blood in stool) typically depends on specific circumstances. Digestive medications can be broadly classified into various types, including pepsin, pancreatin, lipase, among others. Common medications in this category include Omeprazole Enteric-Coated Capsules, Domperidone Tablets, Mosapride Citrate Tablets, and Amoxicillin Capsules.

Pepsin

Pepsin is a digestive protease secreted by the chief cells in the gastric mucosa. It breaks down protein in food into smaller molecules with simpler structures, facilitating absorption by the body. In individuals with gastrointestinal diseases, inadequate pepsin secretion may lead to diarrhea and hematochezia after taking digestive medications, commonly observed in patients with gastritis or gastric ulcers.

Pancreatin

Pancreatin is a digestive enzyme secreted by the pancreatic acinar cells. It breaks down protein in food into simpler structures, aiding in absorption. If an individual suffers from pancreatic diseases, taking pancreatin may result in diarrhea and hematochezia.

Lipase

Lipase, secreted by the fat cells in the pancreas, is responsible for digesting and absorbing fat in food. Patients with pancreatic diseases may experience diarrhea and hematochezia after taking lipase.

Others

Medications such as Aspirin Enteric-Coated Tablets and Indomethacin Tablets may irritate the gastrointestinal mucosa, often leading to adverse reactions like diarrhea and hematochezia upon ingestion.

If you experience diarrhea and hematochezia after taking digestive medications, it is recommended to promptly seek medical attention and undergo treatment under the guidance of a healthcare professional. In daily life, maintain a regular diet, avoid overeating, and steer clear of spicy and irritating foods.