What Issues Can a Pre-thrombotic State Indicate?

Prethrombotic state, also known as the prodromal stage of thrombosis, refers to a pathological condition caused by biochemical and hemorheological changes in certain blood components. In this state, the likelihood of thrombosis or thrombotic diseases increases significantly. The prethrombotic state primarily reflects the following issues: 1) Damage or stimulation of vascular endothelial cells; 2) Activation or hyperfunction of platelets and white blood cells; 3) Increased content or activation of coagulation factors; 4) Decreased content or structural abnormalities of anticoagulant proteins; 5) Decreased content or weakened activity of fibrinolytic components; 6) Increased blood viscosity and slowed blood flow. However, it must be noted that the generally referred to hypercoagulable state is limited to the elevation of plasma levels of coagulation factors and/or their activation within the body, leading to a pathological process of enhanced blood coagulation. In fact, the hypercoagulable state is encompassed within the prethrombotic state. The prethrombotic state is merely a pathological condition of thrombosis and hemostasis that can persist for a long time, often without specific symptoms or signs in clinical settings.