Why Does Platelet Count Keep Decreasing in Leukemia Patients?

Reasons for Persistent Decline in Platelet Count in Leukemia Patients and Corresponding Treatments

The persistent decline in platelet count among leukemia patients may stem from various causes such as disease progression, hypersplenism, bone marrow suppression, among others. Targeted treatments can be administered under medical guidance based on the specific underlying reasons. Here are the details:

1. Disease Progression

If the patient's symptoms continue to worsen, it indicates disease progression. In the late stages of leukemia, thrombocytopenia (low platelet count) may occur. Patients can undergo targeted therapy with drugs like tyrosine kinase inhibitors as prescribed by their doctors.

2. Hypersplenism

Hypersplenism is a splenic disorder caused by overactive spleen function. This condition leads to a reduction in all blood cell types, including platelets. Surgical removal of the spleen (splenectomy) is recommended under medical advice.

3. Bone Marrow Suppression

Bone marrow suppression refers to decreased hematopoietic function in the bone marrow, resulting in lower white blood cell and platelet counts. This is primarily due to abnormal bone marrow function and can also cause persistent platelet decline. Chemotherapy, radiotherapy, and other treatments as prescribed by doctors are recommended.

4. Other Causes

Other factors include medications, infections, and immune disorders. Common medications that may affect platelet count include antibiotics like Penicillin V Potassium Tablets, antivirals like Acyclovir Tablets, and immunosuppressants like Dexamethasone Acetate Tablets. Long-term use of these drugs may suppress platelet production and reduce platelet count. Switching to alternative medications under medical advice is advised.

When leukemia patients experience persistent platelet decline, it is crucial to promptly consult a hematologist and undergo blood tests, bone marrow examination, and other relevant tests for accurate diagnosis. During treatment, patients should rest adequately and avoid strenuous activities in public places to prevent bleeding.