Factors Contributing to Gout

Gout can be attributed to numerous factors, including genetics, improper diet, and medication effects. Obesity, hyperlipidemia, and hypertension also elevate the risk of developing gout.

Primary Factors

1. Genetics:

   If gout runs in the family, individuals are more likely to develop the condition.

2. Improper Diet:

   Long-term excessive consumption of purine-rich foods, such as animal viscera, seafood, and soy products, can lead to elevated uric acid levels, triggering gout attacks.

3. Medication Effects:

   Certain medications, including anti-tuberculosis drugs like Rifampicin Capsules and Pyrazinamide Tablets, as well as immunosuppressants like Aspirin Enteric-coated Tablets and Cyclosporine Soft Capsules, can cause abnormal increases in uric acid levels, precipitating acute gout episodes.

Secondary Factors

1. Obesity:

   People with overweight or obesity have high fat content in their bodies, which can increase blood uric acid concentrations, leading to crystallization and deposition in joints, triggering gout.

2. Hyperlipidemia:

   Dyslipidemia disrupts uric acid excretion, causing uric acid levels to rise and increasing the risk of gout.

3. Hypertension:

   Poor blood pressure control may impair kidney function, impeding the excretion of excess uric acid, causing its accumulation in the body and ultimately leading to gout.

In addition to the above, conditions like diabetes and nephrotic syndrome may also increase the risk of gout. It is recommended to maintain a balanced diet, avoid excessive alcohol consumption and high-purine foods, to prevent disease progression.