IgA Nephritis, also known as IgA nephropathy, is a chronic kidney disease primarily characterized by IgA or IgA deposition. Its pathogenesis is not fully understood, but it may be related to factors such as genetics, infection, and immune disorders. Here are some details:
1. Genetics: Studies have shown that IgA nephropathy has a certain familial aggregation, and the risk of developing the disease among relatives of patients is significantly higher than that of the general population. Some studies have found that genetic mutations in some patients are also associated with the occurrence of the disease.
2. Infection: Bacterial or viral infections can trigger immune responses in the body, leading to an increase in immunoglobulin levels and thus causing IgA nephropathy. This is commonly seen in respiratory tract infections, intestinal infections, etc.
3. Immune Disorders: When the body experiences abnormal immune function, such as autoimmune diseases like systemic lupus erythematosus and Sjögren's syndrome, as well as allergic purpura and other allergic diseases, it may lead to the development of IgA nephropathy.
4. Others: Factors such as drugs and environmental factors can also induce IgA nephropathy. For example, long-term use of non-steroidal anti-inflammatory drugs, penicillin antibiotics, and other medications may damage kidney cells and cause the disease. Additionally, long-term exposure to heavy metals, chemical poisons, and other environmental factors may also increase the risk of developing the disease.
For patients diagnosed with IgA nephropathy, it is essential to avoid fatigue and infections in daily life and undergo standardized treatment according to the doctor's instructions.
