What Does an Antithyroid Peroxidase Level of 1300 Mean, and What Should I Do?

When undergoing thyroid examination, it typically includes testing for T3, T4, thyroglobulin, and peroxidase, among others. If the patient's test results show peroxidase levels at 1300, the possibility of chronic thyroiditis should be considered. If both T3 and T4 levels are normal, no special treatment is required. However, if hypothyroidism is indicated in thyroid function, medication treatment is necessary.

Elevated thyroid peroxidase levels indicate the presence of chronic immune inflammation in the body. Tpo is an important indicator in thyroid function tests. A peroxidase level of over 1300 suggests chronic thyroiditis, also known as Hashimoto's thyroiditis. If thyroid function and T3, T4 levels are normal, no special treatment is required. If hyperthyroidism is indicated but asymptomatic, no treatment is necessary. However, if hypothyroidism is present, replacement therapy with levothyroxine is recommended.

Chronic thyroiditis, also known as Hashimoto's disease or Hashimoto's thyroiditis, is a non-infectious autoimmune disease caused by immune dysfunction that leads to immune inflammation targeting the body's own tissues. Its etiology is unknown, with genetic and autoimmune factors interacting to cause the disease. It can be associated with conditions such as pernicious anemia, systemic lupus erythematosus, and rheumatoid arthritis. More than 90% of cases occur in women. Clinically, it may be asymptomatic, manifesting primarily as painless diffuse enlargement of the thyroid gland. In a minority of cases (less than 5%), hyperthyroidism may be present. The disease has a long duration, and hypothyroidism may gradually develop in most cases.

1. After consuming large amounts of pungent and fishy foods, patients may experience thyroid enlargement and pain. Some may also develop symptoms of hyperthyroidism.

2. Thyroid enlargement is often tender with no vascular murmur and may present with nodules.

3. Thyroid enlargement during adolescence.

4. Localized mucinous edema on the front of the calves.

5. Patients' hyperthyroid symptoms can resolve spontaneously without medication, and this can occur repeatedly.

6. Patients may experience both hyperthyroid and hypothyroid symptoms.

1. Hashimoto's hyperthyroidism: Patients present with typical symptoms of hyperthyroidism and positive laboratory test results. Hyperthyroidism and Hashimoto's disease can coexist or occur sequentially, with mutual coexistence and transformation.

2. Pseudo-hyperthyroidism: A minority of patients may exhibit symptoms of hyperthyroidism, but thyroid function tests do not provide evidence of hyperthyroidism, and TGAb and TMAb are positive.

3. Exophthalmos type: Eye protrusion, with normal, hyperactive, or hypoactive thyroid function.

4. Subacute thyroiditis-like type: Acute onset with thyroid pain and fever, accelerated erythrocyte sedimentation rate, but normal or increased iodine-131 uptake, and positive thyroid antibody titers.

5. Adolescent type: Accounts for approximately 40% of thyroid enlargement in adolescents, with normal thyroid function and lower antibody titers.

6. Fibrotic type: Longer duration with extensive or partial fibrosis of the thyroid gland, thyroid atrophy, and hypothyroidism.

7. Associated with thyroid adenoma or cancer: Often presents as isolated nodules with higher TGAb and TMAb titers.