What Are the Side Effects of Nicardipine Injection?

Update Date: 2024-06-12 Source: Network

Common side effects of nicardipine injection mainly include headache, dizziness, flushing, and edema in the feet. These are caused by vasodilation after injection. Additionally, nicardipine injection may also lead to symptoms such as palpitations and worsening of angina pectoris. Generally, these symptoms can be resolved by reducing the dosage. Such side effects are relatively rare. Some patients may also experience nausea, constipation, and other symptoms.

Side Effects of Nicardipine Injection

1. Common side effects include edema in the feet, dizziness, headache, and flushing, all resulting from vasodilation.

2. Less common side effects include palpitations, tachycardia, and worsening of angina pectoris, often caused by reflex tachycardia. These symptoms can be corrected by reducing the dosage or adding β-blockers.

3. Rare side effects include nausea, dry mouth, constipation, fatigue, and rash.

4. Occasionally, there may be an increase in blood urea nitrogen (BUN), creatinine, serum bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase.

5. Rarely, granulocytopenia may occur, and the drug should be discontinued if abnormalities are observed.

Precautions for Injection of Nicardipine

1. For hypertensive emergencies, blood pressure may rise again after stopping the medication. Therefore, it is necessary to gradually reduce the dosage when discontinuing the medication and closely monitor blood pressure changes after discontinuation. Additionally, it is important to be aware of rebound hypertension when switching to oral administration.

2. When administering this medication for a long period, if pain or redness occurs at the injection site, the injection site should be changed.

3. There may be individual differences in the effect of the medication. Therefore, it is essential to closely monitor changes in blood pressure and heart rate during administration.

4. Patients with impaired liver or kidney function and patients with aortic stenosis should be administered this medication with caution.