What Causes High Uric Acid Levels?
High uric acid levels mainly refer to the concentration of uric acid in the blood exceeding the normal range. The causes are complex and diverse, potentially related to genetic factors, dietary factors, medication factors, metabolic abnormalities, and renal dysfunction.
Genetic Factors: Some families may have a genetic predisposition to hyperuricemia, where uric acid levels may rise even without other obvious triggers. This is associated with genetic differences in individual purine metabolism capabilities, particularly abnormalities in the urate secretion function of renal tubules, resulting in reduced uric acid excretion capacity in the body.
Dietary Factors: Long-term intake of high-purine foods, such as animal internals, seafood, and meat broth, can lead to excessive uric acid production. Additionally, excessive alcohol consumption increases uric acid production and decreases uric acid excretion, leading to elevated uric acid levels.
Medication Factors: Drugs such as quinolones and penicillins may inhibit uric acid excretion, while diuretics like Furosemide and Hydrochlorothiazide may interfere with glomerular uric acid excretion, leading to excessively high uric acid levels in the body.
Metabolic Abnormalities: Metabolic abnormalities include diabetes, high cholesterol, and gammaglobulinemia, which interfere with the balance of purine metabolism in the body, leading to increased uric acid production and difficult renal excretion.
Renal Dysfunction: If renal function is impaired, such as in glomerular nephritis, nephrotic syndrome, and other renal diseases, uric acid cannot be normally excreted, resulting in high uric acid levels. Additionally, renal insufficiency leads to uric acid accumulation in the body due to renal metabolic dysfunction and decreased glomerular filtration rate.
Precautions: When treating high uric acid levels, it is necessary to comprehensively consider the patient's specific circumstances and adopt targeted treatment measures. At the same time, patients should also improve their lifestyle and dietary habits to reduce uric acid production and promote uric acid excretion.
