What are the Effects of Oxybutynin HCl Tablets?
Hydrochloride Oxybutynin Tablets are antispasmodic drugs used to relieve symptoms related to urination in patients with non-inhibitory and reflux neurogenic bladder dysfunction.
Hydrochloride Oxybutynin Sustained-release Tablets have a direct antispasmodic effect on smooth muscle and can inhibit the muscarinic action of acetylcholine on smooth muscle. They can selectively act on the detrusor muscle of the bladder, reduce intravesical pressure, increase bladder capacity, and reduce involuntary bladder contractions to relieve urgency, frequent urination, and urinary incontinence. The anticholinergic activity of hydrochloride oxybutynin sustained-release tablets on the detrusor muscle of rabbits is only 1/5 of atropine, but its antispasmodic effect is 4-10 times that of atropine. Hydrochloride Oxybutynin Sustained-release Tablets have no blocking effect on skeletal muscle ganglion and autonomic ganglion.
After the first dose of hydrochloride oxybutynin sustained-release tablets is taken orally, the blood drug concentration continues to rise within 4-6 hours, and the maintenance of a stable blood drug concentration lasts for nearly 24 hours. Compared with ordinary oxybutynin preparations, the relative bioavailability of R-oxybutynin and S-oxybutynin in hydrochloride oxybutynin sustained-release tablets is 156% and 187% respectively. The shape of the blood drug concentration-time curve of R-oxybutynin and S-oxybutynin is roughly the same. After multiple doses of hydrochloride oxybutynin sustained-release tablets, the plasma reaches a steady-state concentration after 3 days, and no drug accumulation or changes in pharmacokinetic parameters of oxybutynin and desethyl oxybutynin have been observed. Food does not affect the absorption and metabolism of hydrochloride oxybutynin sustained-release tablets.
The effectiveness and safety of using this product in children under 6 years of age have not been established. It is contraindicated in patients with glaucoma, and should be used with caution in patients with liver or kidney diseases and pregnant women.
