Knees are clinically referred to as knee joints. Weakness in knee joints after uremia is generally caused by electrolyte imbalance, osteoporosis, anemia, calcium-phosphorus metabolism disorder, etc. resulting from uremia. Appropriate treatment measures can be taken according to different reasons. 1. Electrolyte imbalance: Patients with uremia have severe kidney dysfunction, and urine output will be significantly reduced, leading to abnormal excretion of water and metabolites in the body. When electrolyte imbalance occurs in the body, it will lead to symptoms of general fatigue, and severe cases may manifest as weakness in knee joints. The main treatment is to correct electrolyte imbalance, and drugs for calcium-phosphorus metabolism disorder can be prescribed, such as calcium carbonate, calcium acetate, magnesium carbonate, etc. At the same time, oral stone removal drugs such as stone removal granules can be taken. If necessary, kidney replacement therapy such as hemodialysis and peritoneal dialysis can be performed. 2. Osteoporosis: It is a common complication of uremia because long-term uremia can lead to calcium-phosphorus metabolism disorder, causing osteoporosis and thus manifesting as weakness in knee joints. Bisphosphonates can be prescribed for the treatment of osteoporosis, and foods high in calcium, such as dairy products and fish, can be consumed daily. 3. Anemia: Patients with uremia often experience poor appetite, nausea, vomiting, and other symptoms, leading to nutritional deficiency and anemia. Patients with severe anemia may experience weakness in knee joints. The main treatment is to supplement iron, folic acid, vitamin B12, and other drugs. Daily diet can include foods such as pig liver and duck blood. 4. Calcium-phosphorus metabolism disorder: Patients with uremia have severe kidney dysfunction, and their ability to excrete calcium and phosphorus will decrease, leading to high blood calcium and low blood phosphorus, which can cause osteoporosis and manifest as weakness in knee joints. The main treatment is to supplement drugs for calcium-phosphorus metabolism disorder, such as calcium carbonate, calcium acetate, magnesium carbonate, etc., on the basis of kidney replacement therapy. Daily diet should include foods rich in calcium and phosphorus, such as dairy products and fish. If you experience weakness in knee joints, it is recommended to seek medical attention promptly and undergo appropriate treatment under the guidance of a doctor.