"How to Conduct Genetic Testing for Leukemia?"

Update Date: 2024-08-28 Source: Network

Genetic testing is a relatively common clinical examination method, and it is particularly important for patients with leukemia. However, in clinical practice, since the genetic mutation sites in leukemia patients mostly occur on chromosomes, appropriate genetic testing protocols can be selected based on the situation. Commonly used genetic testing protocols include NGS, PET-CT, next-generation sequencing (NGS), among others.

1. NGS (Next-Generation Sequencing)

Also known as peripheral blood hematopoietic stem cell transplantation, NGS typically involves chromosomal karyotype analysis of peripheral blood hematopoietic stem cells after testing peripheral blood samples from patients. Based on the results, it determines whether the patient has chromosomal abnormalities and whether further genetic testing is necessary.

2. PET-CT

Following the peripheral blood sample test, a PET-CT examination is conducted to more comprehensively observe the metabolic and other functional conditions within the body of leukemia patients. This examination provides important reference value for staging leukemia, detecting the presence of genetic mutations or gene amplifications, among other phenomena.

3. Next-Generation Sequencing (NGS) for Peripheral Blood

Also known as second-generation genetic testing for peripheral blood, this method primarily utilizes instruments such as PET-CT to sequence the gene sequences of peripheral blood cells throughout the body of leukemia patients. Based on the results, it determines whether there are leukemia cell surface-related genes present, and subsequently identifies the type of leukemia.

4. Chromosomal and Genetic Testing for Leukemia

This usually refers to testing the chromosomes and genes of leukemia patients. As leukemia is often caused by chromosomal abnormalities, second-generation sequencing can detect these abnormalities, thereby facilitating the diagnosis and treatment of leukemia. If one wishes to determine whether a leukemia patient has genetic mutation sites, genetic testing can be performed directly. However, due to the numerous genetic mutation sites in leukemia, screening for potential mutation sites before testing is necessary to improve accuracy.