What is the Instruction Manual for Heterocyclic Phosphoramide?

Heterocyclic phosphoramide is mainly used to treat sarcomas, ovarian cancer, and other diseases. It has a relatively good inhibitory effect on tumors. However, it cannot be used by individuals with abnormal liver and kidney function or women of reproductive age. Incorrect use may cause adverse reactions such as drowsiness. The instructions usually mainly introduce the efficacy, contraindications, adverse reactions, etc. of the drug. It is important to pay attention to checking the date before using the drug.

The effect of heterocyclic phosphoramide is generally suitable for testicular cancer, ovarian cancer, breast cancer, sarcomas, malignant lymphoma, and lung cancer, etc. It has no anticancer activity in vitro, but after entering the body, it is hydrolyzed by phosphoramidase or phosphatase present in the liver or tumor into active phosphoramide metabolites that play a role. It is suitable for anti-tumor spectra and has inhibitory effects on various tumors.

The metabolites of this product can stimulate the urinary tract. When used, patients should be encouraged to drink plenty of water. When used in large doses, hydration and diuresis should be performed, and urinary tract protectants such as mesna should be given at the same time. Caution should be exercised in patients with hypoalbuminemia, liver and kidney dysfunction, bone marrow suppression, and women of reproductive age. The aqueous solution is unstable and should be prepared and used immediately. Regular blood tests for white blood cells, platelets, and liver and kidney function should be performed during medication.

The bone marrow suppression of this product is particularly severe. Individual patients may experience drowsiness, lethargy, and disorientation. These adverse reactions can be relieved and disappear completely after stopping the medication. If the adverse reactions are too severe, the medication should be discontinued.