Gentamicin and Its Usage

Gentamicin is an injectable solution that exhibits excellent antibacterial and bactericidal effects against both Gram-negative and Gram-positive bacteria. However, it also carries significant side effects, primarily manifesting as ear damage, causing symptoms such as dizziness, vertigo, and tinnitus in patients. Additionally, while some individuals may use gentamicin topically, its application should be done with caution despite its effectiveness on affected areas.

Risks Associated with Topical Use of Gentamicin

1. Prolonged use of gentamicin is not recommended, and therefore, it is crucial to clearly understand the considerations involved in the treatment process. Given its classification as a Gram-negative bacterium, its reaction to gases must also be carefully assessed. Topical application of gentamicin is primarily used to treat skin diseases. It is essential to have a clear understanding of the application method and related procedures to effectively treat and alleviate symptoms.

2. The method of topical application of gentamicin should be carefully considered. Generally, the use of antibiotics is not recommended under non-special circumstances to avoid adverse drug reactions and the development of antibiotic resistance. A bland diet, avoiding spicy and stimulating foods, is advisable. When deciding to use topical application for treatment, it is crucial to have a clear understanding of related matters, particularly those related to lifestyle and diet, as they play a significant role in the treatment process. Failure to do so may result in incomplete improvement of symptoms. Ensuring adequate sleep, maintaining emotional stability, and adhering to medical advice when using medication are essential to ensure its efficacy.

Indications for Gentamicin

1. It is indicated for the treatment of neonatal septicemia and septicemia caused by sensitive bacteria.

2. It is suitable for the treatment of respiratory infections, peritonitis, biliary infections, and other conditions caused by sensitive bacteria.

3. It is indicated for the treatment of urogenital infections caused by sensitive bacteria (excluding uncomplicated initial urinary tract infections).

4. It is used for the treatment of skin and soft tissue infections, burn infections, and other conditions caused by sensitive bacteria.

5. Oral administration can be used for intestinal infections or as a preoperative preparation for colon surgery.

6. Intramuscular injection combined with clindamycin or metronidazole can be used to reduce the incidence of post-colon surgery infections.

7. Intrathecal injection can be used as an adjunctive treatment for severe central nervous system infections (acute suppurative meningitis, ventriculitis) caused by Pseudomonas aeruginosa or Staphylococcus.

8. Gentamicin can also be used to treat Listeria monocytogenes infections.

9. Gentamicin eye drops are indicated for the treatment of conjunctivitis, keratitis, dacryocystitis, blepharitis, tarsal gland inflammation, and other conditions caused by coagulase-negative and positive Staphylococcus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, other Gram-negative bacilli, and Neisseria gonorrhoeae.