What Are the Functions and Benefits of Actos Pioglitazone Hydrochloride Tablets?

Update Date: 2024-05-23 Source: Network

Many people are not familiar with Actos hydrochloride pioglitazone tablets, which is a common medication used to treat type 2 diabetes. We know that diabetes is a relatively common chronic disease that poses significant harm to patients, and there is currently no effective cure for diabetes. Only by controlling patients' symptoms through medication can the condition be stabilized and the onset of diabetes delayed. Let's briefly understand this aspect.

1. Increasing the effect of insulin in peripheral tissues

Increasing the effect of insulin on the hindlimb soleus muscle of Wistar obese rats (promoting glycogen synthesis and glycolysis) (in vitro experiments). Also, increasing the effect of insulin in free adipocytes in the epididymal adipose tissue of Wistar obese rats (promoting glucose oxidation and total lipid synthesis) (in vitro experiments).

2. Enhancing the effect of insulin in the liver

Promoting the activity of hepatic glucokinase and reducing the activity of 6-phosphoglucomutase in Wistar obese rats, inhibiting glucose production (in vivo experiments).

3. Enhancing the effect of insulin receptors

Restoring the phosphorylation of reduced insulin receptors and insulin receptor substrates in the skeletal muscle of Wistar obese rats, promoting the activity of phosphatidylinositol-3-kinase (in vivo experiments).

4. Inhibiting the production of TNF-α

Inhibiting the production of TNF-α in the skeletal muscle of Wistar obese rats while reducing hyperglycemia (in vivo experiments).

5. Scope of application

For patients with type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), Actos hydrochloride pioglitazone can be used in combination with dietary control and exercise to improve and control blood sugar levels. Actos hydrochloride pioglitazone can be used independently, and when dietary control, exercise, and monotherapy cannot satisfactorily control blood sugar levels, it can also be used in combination with sulfonylureas, metformin, or insulin. The control of type 2 diabetes should also include nutritional counseling, necessary weight loss, and exercise. This diligence is not only important during the initial treatment of type 2 diabetes but also during maintenance treatment with medication.