What are the Effects and Benefits of Cefmetazole?

Cefmetazole is a commonly used western medicine that primarily belongs to the class of antibiotics. It exhibits excellent antibacterial effects against various bacteria. When using cefmetazole, it is crucial to follow medical advice and refrain from self-medication to avoid incorrect treatment or potential harm from drug side effects. So, what are the specific functions and effects of cefmetazole? Let's briefly explore this aspect.

Cefmetazole is a semi-synthetic cephamycin derivative with antibacterial properties similar to second-generation cephalosporins. Its antibacterial mechanism is similar to other cephalosporin drugs, primarily achieved through interference with bacterial cell wall biosynthesis. Structurally, cefmetazole is comparable to cephalosporins, but the presence of a methoxy group at the 7-position carbon atom of its cephamycine nucleus enhances its stability against various β-lactamases, allowing it to exert effective antibacterial activity against even strains resistant to other cephalosporins.

Cefmetazole demonstrates strong antibacterial activity against Staphylococcus, Escherichia coli, Klebsiella, indole-negative or positive Proteus, Bacteroides fragilis, and other bacteria.

⑴ Cefmetazole sodium is highly stable against β-lactamases and exhibits strong antibacterial activity against both β-lactamase-producing and non-producing sensitive bacteria.

⑵ It has good antibacterial effects against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Additionally, it exhibits strong antibacterial activity against common Proteus, Morganella morganii, and Providencia species that are resistant to cephalosporins and penicillin antibiotics. Furthermore, it demonstrates strong antibacterial activity against anaerobic bacteria such as Peptostreptococcus, Bacteroides, and Prevotella (excluding Prevotella bivia).

Subcutaneous administration experiments in young rats have reported testicular atrophy and suppression of spermatogenesis. Studies exploring the antigenicity of cefmetazole sodium in mice, rabbits, and guinea pigs revealed weak antigenicity similar to other cephalosporin antibiotics. Cross-reactivity with passive cutaneous anaphylactic reactions to cefazolin and cephalexin was also relatively weak. Additionally, the Kumms positive reaction was significantly weaker compared to cephalexin.