"At What Age Do People Develop Uremia?"

Update Date: 2024-09-18 Source: Network

Age of Onset of Uremia

There is no specific numerical value for the age of onset of uremia in clinical practice. Uremia is a syndrome comprising a series of clinical manifestations that arise when chronic kidney disease progresses to its end stage. The causes of uremia may be related to the accumulation of toxic substances in urine, as well as electrolyte imbalance, acid-base balance disorder, hypertension, infection, and other factors.

1. Accumulation of Toxic Substances in Urine: Patients with chronic kidney disease generally have low glomerular filtration rates. When metabolic products in urine, such as urea nitrogen and creatinine, accumulate to a certain extent, they can damage the kidneys, leading to the development of uremia.

2. Electrolyte Imbalance: Patients with uremia often have electrolyte imbalances, primarily due to metabolic disorders of hydrogen ions, sodium ions, and potassium ions secreted by the renal tubules. Additionally, when patients develop diabetic acidosis due to diabetic nephropathy, it may also lead to electrolyte imbalances.

3. Acid-Base Balance Disorder: Patients with uremia commonly experience acidosis and electrolyte imbalances. Metabolic acidosis is more common, which is primarily caused by decreased hydrogen ion secretion by renal tubules, leading to increased hydrogen ion reabsorption and increased excretion of bicarbonate ions.

4. Hypertension: Hypertension is often associated with the progression of chronic kidney disease. Poor blood pressure control can exacerbate renal function impairment, gradually leading to uremia.

5. Infection: Patients with uremia often experience infections due to the inability to timely excrete toxins from the body. The accumulation of toxins can lead to infectious diseases such as pneumonia and enteritis.

In addition to these relatively common causes, there are other possible diseases, such as renal ischemia. Patients with uremia are generally treated with hemodialysis or peritoneal dialysis, and kidney transplantation can also be considered if conditions permit.