What are the Types of Gastric Mucosal Protective Agents Available?

Despite significant improvements in material living standards, many people do not maintain good eating habits in their daily lives, which can easily lead to various gastrointestinal diseases, especially stomach diseases. It is necessary to use medication and gastric mucosal protective agents to minimize irritation and injury to the stomach. So, what are gastric mucosal protective agents? Let's take a look below.

1. Colloidal Bismuth Subcitrate, such as Del and Lizhu Del granules, forms a solid vanadium oxide colloidal precipitate on the ulcer surface or ulcer base granulation tissue under gastric juice pH conditions, serving as a protective film to isolate gastric acid, enzymes, and food from erosive effects on ulcerated mucosa, promoting the repair and healing of ulcerated tissue. Additionally, it can deactivate pepsin through chelation, and bismuth ions can promote mucus secretion, which also contributes to ulcer healing. It is used for the treatment of gastric and duodenal ulcers, with a dosage of 1 packet (300 mg) four times daily, half an hour before meals and before bedtime. If it is a mixture, the dosage is 5 ml three times daily, diluted with three times the amount of boiling water, and a course of treatment is six weeks.

2. Sucralfate, a sucrose sulfate alkaloid or aluminum salt, can chelate with pepsin to inhibit its decomposition activity; it can also chelate with gastric mucosal proteins to form a protective film with acid-suppressing effects and promote mucosal regeneration and enhance resistance. It is used for ulcer diseases, but the efficacy is slow, with symptoms improving after about two weeks of use, and ulcer healing occurring within 3-6 months. The dosage is 1.0 gram four times daily, taken 2-3 hours after meals.

3. Gastromucin, extracted from the gastric mucin of pigs, forms a very viscous gelatinous substance when exposed to acid, which attaches to the gastric mucosa to protect ulcerated areas and promote healing. The dosage is 50 grams four times daily.

4. Maizilin-S granules contain 3 mg of water-soluble oligomeric proline per gram and 990 mg of L-glutamine, which can promote ulcer healing and inhibit the digestive system mucosal lesions caused by aspirin and non-steroidal drugs (such as indomethacin). It can also inhibit the secretion of pepsin and is used to treat chronic gastritis, gastric, and duodenal ulcers.

5. Lizhu Xinluowei is a gastric mucosal protective factor enhancer that can enhance the vitality of gastric mucosal cells, nourish locally damaged mucosa, and promote the repair of epidermal cells and fibroblasts. It is mainly used to treat gastric and duodenal ulcers.

6. Other agents include Hericium erinaceus tablets, prostaglandins, and antacids such as Weibizhi, Weidele, Ledewei, and Bingguanamine, which also have protective effects on the gastric mucosa. Currently, it is believed that antibacterial drugs such as Furazolidone can also enhance the barrier function of the gastric mucosa.