What is the pathology of polymorphic gastric ulcer?

Variable gastric ulcer refers to the repeated process of damage and repair of the epithelial layer of the gastric mucosa. This lesion is usually related to Helicobacter pylori infection, long-term use of non-steroidal anti-inflammatory drugs, and other factors.

1. Helicobacter pylori infection: Helicobacter pylori is a bacteria that can survive in a gastric acid environment, causing inflammation of the gastric mucosa, leading to damage and ulcer formation in the gastric mucosa;

2. Long-term use of non-steroidal anti-inflammatory drugs: Some patients may need to take aspirin and other non-steroidal anti-inflammatory drugs for other diseases for a long time. These drugs inhibit prostaglandin synthesis, reduce gastric mucus secretion, and damage the gastric mucosa, thus increasing the risk of variable gastric ulcer.

The symptoms of variable gastric ulcer include abdominal pain, nausea, vomiting, anorexia, weight loss, etc. Vomiting blood or black stool may also occur.

For variable gastric ulcer caused by Helicobacter pylori infection, quadruple therapy is generally used for radical treatment, which includes one proton pump inhibitor, two antibiotics, and one bismuth agent. Commonly used proton pump inhibitors are omeprazole, lansoprazole, etc.; commonly used antibiotics are clarithromycin, amoxicillin, etc.; commonly used bismuth agents are potassium bismuth citrate, colloidal bismuth pectin, etc. At the same time, attention should be paid to maintaining a healthy diet, avoiding spicy and stimulating foods such as chili and Sichuan peppercorns. If the above symptoms occur, it is recommended to seek medical attention promptly and undergo relevant examinations and treatments under the guidance of a doctor.

In daily life, it is important to maintain good living habits, regular schedules, sufficient sleep time, and avoid overwork.