What Are the Side Effects of Rabeprazole?
The correct name for Lebailazuo is Rabeprazole. Rabeprazole can inhibit gastric acid secretion and fight Helicobacter pylori. However, during its use, it may cause adverse reactions such as reduced red blood cells and lymphocytes, diarrhea, nausea, headache, dizziness, rash, itching, and other side effects.
1. Rabeprazole may cause a decrease in red blood cells and lymphocytes, as well as changes in white blood cell counts, with either a decrease or increase. It may also lead to an increase in eosinophils and neutrophils. If any of these conditions occur, the medication should be discontinued immediately, and appropriate measures should be taken.
2. Possible adverse reactions include diarrhea, nausea, rhinitis, abdominal pain, fatigue, bloating, and dry mouth, which may disappear after discontinuation of the drug. There may also be liver abnormalities such as elevated transaminase levels.
3. In the nervous system, symptoms such as headache, dizziness, drowsiness, limb weakness, decreased sensation, reduced grip strength, slurred speech, and unsteady gait may be observed.
4. Other occasional side effects may include rash, itching, edema, elevated total cholesterol and urea nitrogen, and proteinuria. If any of these abnormalities occur, the medication should be discontinued immediately, and appropriate measures should be taken.
1. Rabeprazole sodium can produce a sustained inhibitory effect on gastric acid secretion. As rabeprazole sodium decreases acidity, it interacts with drugs whose absorption is related to gastric pH levels. For example, it can reduce the bioavailability of ketoconazole by approximately 30% and increase the AUC and Cmax values of digoxin by 19% and 29% respectively. Therefore, patients should be monitored when taking these drugs concurrently with rabeprazole sodium.
2. When rabeprazole sodium is taken concurrently with antacids or taken one hour after antacids, the area under the plasma concentration-time curve for rabeprazole decreases by 8% and 6% respectively. This indicates that the interaction between rabeprazole and antacids may affect the absorption and efficacy of the drug.
Note: The above information is only intended as an introduction, and the use of drugs must be carried out under the guidance of a doctor in a formal hospital.
When rabeprazole is used concomitantly with antibiotics to eradicate Helicobacter pylori, it should be taken in the morning before meals. Additionally, the use of this medication may mask symptoms caused by gastric cancer, so it should only be administered after excluding the possibility of malignancy.
