"How Should Medication for Gout Disease Be Administered?"

Gout: A Heterogeneous Disease Related to Purine Metabolism Disorder or Uric Acid Excretion Impairment

Gout is a heterogeneous disease caused by purine metabolism disorders or uric acid excretion impairments. Clinically, it primarily manifests as recurrent arthritis, chronic synovitis, tophus formation, and other symptoms. The treatment of gout necessitates the selection of appropriate medications under medical guidance, tailored to the severity of the patient's condition.

I. Acute Phase

During acute gout flares, non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac sodium sustained-release tablets and ibuprofen sustained-release capsules can be prescribed to alleviate pain symptoms. Additionally, glucocorticoids like prednisone acetate tablets and dexamethasone tablets can be administered to reduce swelling and pain.

II. Intercritical and Chronic Phases

1. Uric Acid-Lowering Drugs: In the intercritical or chronic stages of gout, uric acid-lowering medications are prescribed to control blood uric acid levels, thereby reducing the risk of recurrent gout attacks. Commonly used drugs include allopurinol tablets, febuxostat tablets, and benzbromarone tablets.

2. Colchicine: During acute gout flares, short-term use of colchicine can be prescribed to inhibit leukocyte aggregation, mitigate local tissue damage, promote inflammation resolution, and achieve rapid analgesia.

3. Glucocorticoids: If the aforementioned medications prove ineffective, short-term application of glucocorticoids like methylprednisolone tablets and prednisone acetate tablets may be necessary.

Furthermore, it is crucial to maintain a balanced diet, avoiding high-purine foods, to prevent exacerbation of symptoms. Should any other discomfort arise, prompt medical attention is advised to avoid any delay in diagnosis and treatment.