What are the Effects and Benefits of Valsartan and Hydrochlorothiazide Tablets?

Valsartan and hydrochlorothiazide tablets are mainly used to lower blood pressure and belong to a type of antihypertensive drugs. They are very effective for patients with primary hypertension. Middle-aged and elderly people should regularly monitor their blood pressure. If blood pressure rises, treatment should be promptly administered to control blood pressure within a normal range.

1. Valsartan and hydrochlorothiazide tablets are used to treat mild to moderate primary hypertension that cannot be adequately controlled with a single drug. The main component, valsartan, is an orally effective specific angiotensin II (AT1) receptor antagonist. It selectively acts on the AT1 receptor subtype, blocking the binding of Ang II to the AT1 receptor, thereby inhibiting vasoconstriction and aldosterone release, resulting in a hypotensive effect.

2. Valsartan and hydrochlorothiazide tablets do not act on angiotensin-converting enzyme (ACE), renin, or other receptors, and do not inhibit ion channels related to blood pressure and sodium balance. Valsartan lowers elevated blood pressure without affecting heart rate.

3. When valsartan is used in combination with hydrochlorothiazide, the dosage of each drug may need to be adjusted. Valsartan and hydrochlorothiazide tablets are film-coated tablets that appear white or nearly white after removing the coating. They are used to treat mild to moderate primary hypertension that cannot be adequately controlled with a single drug.