The dosage and administration of Clopidogrel Bisulfate Tablets is one tablet twice daily, which can be taken with or without food. However, the specific dosage of this medication needs to be determined based on factors such as the patient's condition and age, and may vary from person to person. It is important to note that if surgery is planned, the medication should be stopped 7 days prior to the procedure.
1. For patients with non-ST-segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction): Therapy should be initiated with a single loading dose of clopidogrel 300mg, followed by a maintenance dose of 75mg once daily (combined with aspirin 75-325mg/day). Due to the increased risk of bleeding with higher doses of aspirin, it is recommended that the aspirin dosage should not exceed 100mg. The optimal duration of therapy has not been formally established. Clinical trial data support the use of medication for 12 months, with the maximum effect observed after 3 months of treatment.
2. For patients with ST-segment elevation acute myocardial infarction: Therapy should be initiated with a loading dose of clopidogrel, followed by a maintenance dose of 75mg once daily, combined with aspirin, with or without thrombolytic agents. For patients over 75 years of age, a loading dose of clopidogrel is not recommended. Combination therapy should be started as soon as possible after the onset of symptoms and continued for at least 4 weeks. There is currently no research to confirm the benefits of combining clopidogrel and aspirin for more than 4 weeks (see Pharmacodynamic Properties).
3. The recommended dosage is 75mg once daily, which can be taken with or without food. No dosage adjustment is required for elderly patients.
For patients with non-ST-segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), therapy should be initiated with a single loading dose of clopidogrel 300mg, followed by a maintenance dose of 75mg once daily (combined with aspirin 75mg~325mg/day). Due to the increased risk of bleeding with higher doses of aspirin, it is recommended that the aspirin dosage should not exceed 100mg. The optimal duration of therapy has not been formally established.
