This may be caused by factors such as nail bed or nail damage, fungal infection, nutritional issues, and more. If the affected area continues to expand or there are other abnormalities, it is recommended to seek medical attention as soon as possible. A seemingly insignificant empty spot in the big toenail may have multiple causes. For instance, mild external impact can cause separation between the nail bed and the toenail, resulting in a "hollow" appearance. Fungal infections often manifest as thickened, yellowed toenails, and even partial detachment. Malnutrition or deficiency of trace elements such as zinc and iron can also make toenails brittle and deformed. If only a small part of the toenail is separated with no other symptoms, observation may be attempted. In daily life, avoiding wearing overly tight shoes is crucial, as prolonged pressure may cause nail bed injuries. Keeping the feet dry and clean can also effectively reduce the risk of fungal infections. Consuming adequate protein, vitamins, and minerals, such as by eating more nuts, green leafy vegetables, and eggs, can strengthen nail health. If symptoms worsen within a few weeks, or are accompanied by toenail discoloration, odor, or pain, it may indicate an infection or a more serious condition. In such cases, immediate examination by a dermatologist or podiatrist is required, who will determine the cause and develop a treatment plan.