Acute gout attacks may be caused by improper diet, medication effects, disease factors, and other reasons. Patients should seek medical attention promptly when experiencing discomfort and receive treatment under medical guidance.
I. Physiological Causes
1. Improper Diet: Regular consumption of high-purine foods, such as seafood or animal organs, in daily life can elevate uric acid levels in the body, thereby inducing acute gout attacks.
2. Medication Effects: Long-term use of diuretics or anti-tuberculosis drugs, like hydrochlorothiazide and isoniazid, may also increase blood uric acid levels, leading to acute gout attacks.
3. Disease Factors: Chronic diseases like kidney disease, diabetes, and hypertension increase the risk of gout because these conditions can impair the body's metabolic function, reducing uric acid excretion and triggering acute gout attacks.
II. Pathological Causes
Gout is a recurrent arthritis, soft tissue damage, and kidney stones caused by excessively high blood uric acid levels. Its clinical features include recurrent joint redness, swelling, heat, pain, and tophus formation, with severe cases potentially leading to joint destruction and deformities. When purine metabolism is impaired, uric acid production increases, and/or excretion decreases, it can elevate blood uric acid concentration. Urate crystal deposits in the skin, joint capsules, bursae, tendons, and other soft tissues, manifesting as varying degrees of acute or chronic inflammatory responses. If urate crystals deposit in joints, it can trigger acute gout attacks.
Patients are advised to maintain a balanced diet, avoiding high-purine foods like pig liver, duck intestines, and chicken hearts. Regular exercise and weight control also help prevent gout attacks.
