Are there any side effects of taking progesterone?

Drinking progesterone has side effects. Also known as progesterone hormone or corpus luteum hormone, it is secreted by the ovaries in the human body and can also be synthetically produced. It has the function of protecting the fetus, treating menstrual disorders, and treating dysfunctional uterine bleeding. In the process of taking it, side effects such as gastrointestinal reactions, mental depression, menstrual disorders, etc. may occur.

1. (1) Gastrointestinal reactions, poor appetite; (2) Acne; (3) Fluid retention and edema; (4) Weight gain; (5) Allergic dermatitis; (6) Mental depression; (7) Breast pain; (8) Changes in female libido; (9) Menstrual disorders, irregular bleeding or amenorrhea; (10) Long-term use can cause endometrial atrophy, reduced menstrual flow, and prone to vaginal fungal infections.

2. Less common adverse reactions include: headache; pain in the chest, buttocks, and legs, especially the calf muscles; weakness, numbness, or pain in the arms and feet; sudden or unexplained shortness of breath, sudden unclear speech, sudden vision changes, double vision, varying degrees of blindness, etc.

3. Long-term use can cause abnormal liver function and an increased incidence of ischemic heart disease; endometrial atrophy, reduced menstrual flow, prone to vaginal fungal infections.

4. The use of progesterone during early pregnancy may cause some progesterone with high androgen activity to masculinize female offspring; offspring may develop reproductive tract malformations, commonly hypospadias.

1. (1) Caution is advised during the first four months of pregnancy, and it is not suitable for use as an early pregnancy test. (2) Use with caution for those with a history of depression. (3) Use with caution for patients with edema.

2. Long-term medication requires attention to liver function tests, especially breast examinations.

3. Currently, natural progesterone is commonly used to treat threatened miscarriage and habitual miscarriage. Synthetically produced progesterone has teratogenic effects on the fetus and must be used with caution.

4. Whether there is a lack of progesterone in premenstrual syndrome is still uncertain, so the use of progesterone for treatment is still controversial, but it is still used clinically.

5. If jaundice occurs, the medication should be discontinued.