Can atropine be used in combination with pilocarpine?

Atropine and pilocarpine are used to treat glaucoma, and these two drugs usually cannot be used together. 1. Can atropine and pilocarpine be used together? Atropine and pilocarpine cannot be used together. Atropine is a typical M-cholinergic receptor blocker, while pilocarpine is a cholinergic drug. Atropine (0.5-1mg subcutaneous injection or intramuscular injection) can counteract and treat excessive poisoning reactions caused by pilocarpine, and maintain normal respiration and circulation. Atropine can counteract the pharmacological effects of pilocarpine, so they cannot be used together. 2. What is the effect of atropine and pilocarpine on the pupil? Atropine is an anticholinergic drug that mainly binds to m-cholinergic receptors. It is a potent ciliary muscle paralytic agent with the effects of regulating paralysis and dilating the pupil. Therefore, atropine can be used for refractive testing in children, as well as the treatment of uveitis and malignant glaucoma. Pilocarpine is a directly acting parasympathetic mimetic drug, commonly used in the treatment of glaucoma. It can contract the pupil sphincter to produce miosis, tighten the iris, and open the anterior chamber angle, thereby reducing intraocular pressure. 3. What is the difference between the effects of atropine and pilocarpine on the eye? Atropine eye drops are eye drops that dilate the pupil, while pilocarpine is eye drops that constrict the pupil. Because the effects of these two types of eye drops are opposite, they are used to treat different diseases. During clinical use, they must be used carefully. Atropine eye drops are generally used for refractive testing in children with refractive errors, or for the treatment of uveitis, malignant glaucoma, etc. While pilocarpine is generally used for the treatment of glaucoma, especially angle-closure glaucoma.