Parecoxib has a certain analgesic effect and is generally used for short-term treatment. The main methods of administration for this drug are intramuscular injection and intravenous injection, which can only be used under a doctor's prescription. Due to its good safety, there are basically no gastrointestinal reactions after use. However, if a patient has just undergone coronary artery bypass surgery, they should not use this drug.
1. The Role of Parecoxib
Parecoxib sodium injection is a non-steroidal anti-inflammatory drug that primarily has analgesic and anti-inflammatory effects. The main component is parecoxib, which is a prodrug of valdecoxib. Valdecoxib is a selective cyclooxygenase-2 inhibitor within the clinical dose range.
2. Adverse Reactions of Parecoxib
Clinical studies have confirmed that parecoxib is safe and effective, with good patient tolerance and a low incidence of gastrointestinal adverse reactions, without causing gastrointestinal mucosal ulceration.
3. Contraindications of Parecoxib
For patients with a high risk of vascular embolism, there are clinically significant differences in antiplatelet activity between some non-steroidal anti-inflammatory drugs with COX-1 inhibitory effects and COX-2 selective inhibitors. COX-2 selective inhibitors reduce the production of prostaglandins in tissues (including endothelial tissue) but have no effect on platelet thromboxane. The clinical relevance of these observations has not yet been established.
