What Causes Chromosome Issues and How Can They Be Treated?

Chromosome issues can be caused by various factors such as physical factors, chemical factors, biological factors, maternal age effect, genetic factors, and autoimmune diseases. There is generally no specific treatment for chromosome abnormalities. Once chromosome abnormalities are discovered, it is important to promptly identify the underlying cause and provide targeted treatment. If chromosome abnormalities are not treated in time, they can affect future fertility and lead to birth defects, causing misfortune to families and society. To avoid infertility caused by chromosome abnormalities, it is necessary to undergo comprehensive medical check-ups before pregnancy and avoid exposure to radiation as much as possible.

1. Physical Factors: Humans are exposed to radiation from both natural and artificial sources. Long-term exposure to radiation and X-ray irradiation can lead to chromosome abnormalities.

2. Chemical Factors: People encounter various chemical substances in their daily lives, some of which are natural and some synthetic. These chemicals can enter the body through diet, respiration, or skin contact and cause chromosome mutations.

3. Biological Factors: When cells are treated with viruses during cultivation, they often undergo various types of chromosome mutations, including breakage, pulverization, and exchange.

4. Maternal Age Effect: During the 6-7th month of fetal development, all oogonia develop into primary oocytes and enter the nucleolar stage from the prophase of the first meiotic division. At this time, the chromosomes become loosely arranged, resembling the former nucleolus, and maintain this state until ovulation during adolescence. As the mother ages, the eggs may undergo many aging changes under the influence of various internal and external factors, affecting the interrelationships between homologous chromosomes during meiotic division and their behavior during the later stages of division, promoting non-disjunction of chromosomes.

5. Genetic Factors: Chromosome issues can be inherited from either parent.

6. Autoimmune Diseases: Autoimmune diseases seem to play a role in chromosome non-disjunction, as there is a close correlation between increased levels of thyroid primary autoantibodies and familial chromosome abnormalities.

Blood samples are taken from both husband and wife to check for chromosomal abnormalities. If abnormalities are found, this belongs to the category of genetic issues, and there is currently no specific treatment available. Chromosome abnormalities are genetic diseases. If both husband and wife have chromosomal issues, it is recommended to perform chromosomal testing on the embryo after pregnancy. If abnormalities are detected, it is advisable to terminate the pregnancy using artificial methods to avoid the birth of a child with problems. Currently, there are no specific diagnostic methods or preventive measures to avoid the formation of malformed embryos. Therefore, it is crucial to undergo relevant checks before or during pregnancy to detect embryos or fetuses with chromosomal abnormalities as early as possible, thereby avoiding the burden of birthing malformed children on families and society.