What are the main causes of developing uremia?

Uremia is a syndrome composed of a series of clinical manifestations that occur after chronic kidney failure enters the terminal stage. The main causes of uremia include primary and secondary kidney damage, obstructive nephropathy, primary glomerulonephritis, hereditary nephropathy, and secondary kidney damage.

1. Primary kidney damage: Common causes include chronic glomerulonephritis, diabetic nephropathy, hypertensive renal arteriolar sclerosis, gouty nephropathy, purpura nephritis, etc. These diseases can lead to the progressive development of chronic kidney disease and ultimately lead to uremia.

2. Obstructive nephropathy: For example, bilateral urinary tract obstruction can lead to impaired kidney excretion function, and some patients ultimately develop uremia. Congenital developmental deformities, such as congenital hydronephrosis, and urethral tumors, may also lead to urinary tract obstruction.

3. Primary glomerulonephritis: It is relatively common in clinical practice and can cause patients to experience symptoms such as proteinuria, hematuria, and hypertension, leading to gradual decline in kidney function and ultimately developing into uremia.

4. Hereditary nephropathy: Such as hereditary nephritis, thin basement membrane nephropathy, etc. These diseases often have a family history and can cause patients to experience progressive renal function decline, ultimately leading to uremia.

5. Secondary kidney damage: Common secondary causes mainly include lupus nephritis, hepatitis B-related nephritis, etc. These diseases can lead to immune dysfunction and ultimately lead to uremia. When patients take medications for a long time, drug-induced kidney injury may occur, which may also cause uremia.

In addition to the above relatively common causes, there are other possible diseases, such as long-term heavy drinking or long-term exposure to organophosphorus drugs, which may also lead to chronic progressive kidney function impairment and ultimately develop into uremia. If patients have the above diseases, they should promptly seek active treatment in the hospital. In daily life, they should also avoid staying up late, being tired, and should undergo regular follow-up examinations to minimize the risk of developing uremia.