Benzoyl peroxide ointment

Benzoyl peroxide ointment has bleaching and bactericidal effects, and can be used clinically to treat acne. However, benzoyl peroxide ointment is a prescription drug that cannot be used randomly by patients and needs to be used under the guidance of a doctor. Benzoyl peroxide ointment is also used for bleaching in many foods, and frequent consumption can definitely have serious health hazards.

I. Introduction

Benzoyl peroxide aqueous gel is a kind of topical medication used to treat ordinary acne. Benzoyl peroxide is an oxidant with bactericidal action and belongs to the class of keratolytic agents. The main ingredient is benzoyl peroxide, with concentrations of 2.5%, 5%, and 10%. The gel matrix consists of docusate sodium, disodium edetate, carbomer 940, silicon dioxide, propylene glycol, poloxamer 182, sodium hydroxide, and purified water. The pH value is adjusted with citric acid.

II. Main Ingredients

The main ingredients of BENZIHEXAC2.5, BENZIHEXAC5, and BENZIHEXAC10 are benzoyl peroxide, with concentrations of 2.5%, 5%, and 10%, respectively. The gel matrix consists of docusate sodium, disodium edetate, carbomer 940, silicon dioxide, propylene glycol, poloxamer 182, sodium hydroxide, and purified water. The pH value is adjusted with citric acid.

III. Clinical Pharmacology

The mechanism of action of benzoyl peroxide is not fully understood, but it is believed to be primarily due to its bactericidal ability against Propionibacterium acnes. Additionally, patients treated with benzoyl peroxide have shown reduced lipid and free fatty acid levels and mild desquamation (dryness and peeling), along with decreased comedones and acne lesions. Although it is known that benzoyl peroxide is metabolized into benzoic acid after absorption through the skin and then excreted in the urine as benzoate, there is still limited knowledge about the percutaneous absorption, metabolism, and excretion of benzoyl peroxide. No reports of systemic toxicity caused by benzoyl peroxide have been observed.

IV. Precautions

This product is for external use only. If severe irritation occurs, discontinue use immediately and seek appropriate treatment. Treatment can be resumed after the symptoms have subsided, with a reduced frequency of application initially. This product should not be used around the eyes or on mucous membranes. Patient Instructions: Avoid contact with eyes, eyelids, lips, and mucous membranes. If contact occurs, rinse with water. Contact with colored substances (including hair and fabrics) may result in bleaching or discoloration. If severe irritation occurs, discontinue use immediately and consult a doctor. The possible presence of benzoic acid is a degradation product of benzoyl peroxide.