What is the meaning of elevated transaminase levels?

1. Transaminase is an important enzyme produced in liver cells, playing a crucial role in amino acid metabolism and the interconversion of proteins, fats, and sugars. It serves as an indispensable "catalyst" in human metabolism and is primarily present in liver cells. When liver cells are inflamed, necrotic, poisoned, or otherwise damaged, transaminase is released into the bloodstream, resulting in elevated serum transaminase levels. Typically, the primary transaminase measured in physical examinations is Alanine Aminotransferase (ALT). 1% damage to liver cells can double the ALT concentration in the blood. ALT levels can sensitively monitor liver damage. Generally, it does not leak out of liver cells in large quantities. If the blood contains a large amount of transaminase, it is considered an abnormal phenomenon. Of course, if only transaminase levels are elevated while other liver function tests are normal or nearly normal, it is referred to as isolated transaminase elevation. At this point, further investigation of the increase in serum transaminase levels is required to understand the extent of liver damage.

2. Elevated transaminase levels are a very common occurrence and do not necessarily indicate liver problems. Since transaminase is highly sensitive, many factors can cause fluctuations in its normal values. Measurements of transaminase in healthy individuals may vary when checked at different times of the day. Early treatments for high transaminase levels often involved the use of Wuwei Ganpian to reduce transaminase levels.