How long does Nimesulide last for pain relief?

Update Date: 2024-06-07 Source: Network

Nimesulide is one of the commonly used analgesic drugs in clinical practice. As a non-steroidal analgesic, it has the functions of antipyretic, analgesic, and anti-inflammatory effects, with analgesic effects lasting for 6 to 8 hours. Nimesulide has a good analgesic effect on post-traumatic pain and pain caused by various diseases, with minimal stimulation to the gastrointestinal tract, and it only needs to be taken orally twice a day.

Like other analgesic drugs, nimesulide should not be taken for a long time to prevent addiction or damage to the liver, kidneys, and other organs. If the pain persists after taking it orally for 3 days and shows a trend of worsening, medical diagnosis and treatment should be sought promptly.

Nimesulide is a second-line drug for anti-inflammatory and analgesic purposes. It is used for the treatment of pain in chronic arthritis (such as osteoarthritis), post-surgical and acute traumatic pain, and primary dysmenorrhea. It should only be used when at least one other non-steroidal anti-inflammatory drug has failed.

This drug is generally well-tolerated, with adverse reactions occasionally including gastric burning, nausea, stomach pain, sweating, facial flushing, hyperactivity, rash, erythema, and insomnia. Headache and dizziness are rare. Patients with renal insufficiency should adjust the dosage. It is recommended to use the minimum effective dose and the shortest course of treatment to reduce the occurrence of adverse drug reactions.

Nimesulide is contraindicated in patients with active peptic ulcer, moderate to severe liver insufficiency, severe renal dysfunction (creatinine clearance rate less than 30ml/min), children under 12 years of age, patients with a history of high sensitivity to this drug, and pregnant women. It should be used with caution in patients allergic to aspirin or other non-steroidal anti-inflammatory drugs, lactating women, patients with bleeding disorders, gastrointestinal diseases, and patients receiving anticoagulant or antiplatelet agents.