Will Taking a Whole Bottle of Colchicine Cause Death?
Colchicine Tablets are suitable for the treatment of gouty arthritis, especially effective for acute gouty arthritis. Additionally, it has a certain preventive effect on gout. Although the treatment effect is good, the side effects of this drug are also relatively strong. If the dosage is excessive, the risk is also relatively high. Therefore, it is necessary to follow the doctor's advice when taking the medication. Let's take a look at the relevant content in this regard.
1. Will taking a bottle of colchicine tablets lead to death? Colchicine Tablets are used for the acute attack of gouty arthritis and the prevention of recurrent acute attacks of gouty arthritis. The maximum oral dosage is not more than 6mg (6-12 tablets) in 24 hours! Large doses can manifest as oliguria, hematuria, convulsions, and consciousness disturbance. The mortality rate is high! The onset rate of toxic effects of drugs is inconsistent. Although the current condition is stable, it is still necessary to send the patient to the hospital for gastric lavage and symptomatic supportive treatment!
2. The main ingredient of colchicine tablets is colchicine, a kind of alkaloid. It is rapidly absorbed in the gastrointestinal tract after oral administration. The plasma protein binding rate is low, only 10% to 34%. The peak blood concentration is reached 0.5 to 2 hours after administration. So, what are the effects and benefits of colchicine tablets?
3. The main effects and benefits of colchicine tablets are the treatment of acute attacks of gouty arthritis and the prevention of recurrent acute attacks of gouty arthritis. Gouty arthritis is a recurrent joint inflammation caused by purine metabolism disorders and elevated blood uric acid. Human uric acid is derived from the breakdown of nucleic acids and other purine compounds metabolized by cells, as well as the breakdown of purines in food. Both increased production and decreased excretion of uric acid can lead to the accumulation of uric acid and the development of hyperuricemia. Deposition of urate in joints, periarticular tissues, and subcutaneous tissues can cause recurrent arthritis, manifesting as acute redness, swelling, and severe pain, gradually leading to bone and joint destruction, deformity, ankylosis, and dysfunction. Gout can be divided into primary and secondary categories. Primary gout may be related to genetic factors. Secondary gout can occur in patients with renal dysfunction and reduced uric acid excretion; it can also occur in patients with leukemia, myeloma, and malignant tumors who have increased nucleic acid breakdown after chemotherapy and radiotherapy.
