The hormones that promote ovulation include clomiphene, human chorionic gonadotropin, luteinizing hormone releasing hormone analogues, and bromocriptine.
1. Clomiphene: Oral administration of 50-150 mg/day of clomiphene should be started from the 5th day of menstruation and continued for 5 days. Ovulation may occur 5-11 days after discontinuation of the drug. If the estrogen level is low, a small dose of estrogen, such as diethylstilbestrol 0.125-0.25 mg/day, can be used for 20 days in 1-3 cycles to increase the sensitivity of the hypothalamus-pituitary-ovarian system. Then, clomiphene can be used to promote ovulation, which can improve the efficacy. If the amount of cervical mucus is small and viscous, diethylstilbestrol 0.125-0.25 mg/day can be added for 7 days after the completion of clomiphene.
2. Human Chorionic Gonadotropin (HCG): HCG has the effect of promoting luteinizing hormone and can promote ovulation when administered near the mature stage of follicle development.
3. Luteinizing Hormone Releasing Hormone Analogues: These are suitable for patients with anovulation due to insufficient secretion from the hypothalamus. Micropump pulse intravenous injection is used with a pulse interval of 90-120 minutes. The small dose is 1-5 μg/pulse, and the large dose is 10-20 μg/pulse. The medication is administered for 17-20 days, or it can be started on the 5th day of the menstrual cycle with daily intramuscular injection of 50 μg for 7-10 consecutive days.
4. Bromocriptine: This drug is suitable for patients with anovulation accompanied by hyperprolactinemia. Many women experience infertility, and upon examination, it is found that the ovaries are not releasing eggs, leading to the need for ovulation-inducing drugs. However, these drugs also have significant side effects. Under drug stimulation, the ovaries may continuously release eggs, leading to premature ovarian failure, irregular menstruation, and even ovarian tumors in severe cases. Therefore, their use should be cautious.
