GPT refers to alanine aminotransferase, also known as glutamic-pyruvic transaminase, which is abbreviated as ALT in English. Although their Chinese and English abbreviations are different, they represent the same clinical significance. Alanine aminotransferase is present in the cells of many organs, but the activity of alanine aminotransferase in liver cells far exceeds that in other organ cells. Current research has shown that alanine aminotransferase is mainly present in the cytoplasm of liver cells. When liver cells are damaged, alanine aminotransferase in the cytoplasm is released into the blood, resulting in an increase in the level of alanine aminotransferase in peripheral blood. Therefore, measuring alanine aminotransferase is of great significance for assessing the degree of liver damage, and it can also be used as one of the sensitive indicators of liver damage.
There are many reasons that can cause an increase in alanine aminotransferase clinically, such as diseases, surgery, anesthesia, strenuous exercise, early pregnancy, taking certain medications, alcohol consumption, and staying up late for a long time. Therefore, it is also necessary to pay attention to discrimination and avoid missed diagnosis and misdiagnosis. If the elevation of glutamic-pyruvic transaminase is caused by alcoholic liver disease, it is necessary to quit drinking. Only by quitting drinking can we prevent and treat alcoholic liver disease. However, during treatment, corresponding drug therapy should also be adopted. Generally, liver-protecting drugs are used to reduce liver damage. Schisandra chinensis, commonly used in clinical practice, contains schisandrin B, which can enhance the detoxification ability of the liver by inducing the activity of hepatic cytochrome P450, increase the synthesis of hepatocyte protein, promote cell repair and regeneration, and thus reduce serum transaminase and protect the liver. The change of nutritional status is closely related to the prognosis of alcoholic liver disease, especially for those who have long-term alcohol consumption and history of liver or digestive system diseases. The supply of nutrition has a significant effect on improving alcoholic liver disease. Vitamin B can provide nutrients required by the liver, maintain normal liver metabolism, and repair liver damage. Patients with elevated glutamic-pyruvic transaminase can increase their intake of edible fungi such as agaric and mushroom in their diet to improve their immunity. Eating high-protein foods can promote the repair and regeneration of liver cells. Additionally, attention should also be paid to the supplementation of fresh vegetables and fruits.
