What are the Effects of Roxithromycin Capsules?

Roxithromycin capsules are a common type of medication that exhibits excellent therapeutic effects against Streptococcus pyogenes. They are frequently prescribed for the treatment of tonsillitis, pharyngitis, or sinusitis. They also demonstrate good therapeutic outcomes in acute episodes of bronchitis, chronic bronchitis, and otitis media. Additionally, they are commonly used in the treatment of pneumonia caused by Mycoplasma pneumoniae and Chlamydophila pneumoniae. Furthermore, they have proven to be effective in the treatment of urethritis and skin and soft tissue infections.

This medication is indicated for the treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis, otitis media, acute bronchitis, acute exacerbation of chronic bronchitis, and pneumonia caused by Mycoplasma pneumoniae or Chlamydophila pneumoniae. It is also used in the treatment of urethritis and cervicitis caused by Chlamydophila trachomatis, as well as skin and soft tissue infections caused by sensitive bacteria.

The main adverse reactions associated with roxithromycin capsules include gastrointestinal symptoms such as abdominal pain, diarrhea, nausea, and vomiting. However, the incidence of these reactions is significantly lower compared to erythromycin. Occasional side effects may include rash, skin itching, dizziness, headache, abnormal liver function (elevated ALT and AST levels), and decreased peripheral blood cell counts.

1. Caution should be exercised when administering this medication to patients with hepatic dysfunction. The elimination half-life (t1/2β) of roxithromycin may be prolonged to more than twice the normal level in patients with severe liver cirrhosis. If necessary, the dosage should be reduced to 150mg once daily.

2. No dosage adjustment is required for patients with mild renal insufficiency. However, for patients with severe renal insufficiency, the dosing interval should be doubled (150mg once daily).

3. Cross-resistance between roxithromycin and erythromycin may exist.

4. To achieve higher blood concentrations, this medication should be taken on an empty stomach (1 hour before meals or 3-4 hours after meals) with water.

5. Regular monitoring of liver function is recommended during the course of treatment.