What does a High Absolute Value of Nucleated Red Blood Cells Mean?

Update Date: 2024-05-28 Source: Network

Red blood cells are a type of cells without a nucleus, and their main components are iron and protein. Their primary function is to transport oxygen. Nucleated red blood cells refer to those that are not fully mature, and their proportion in the body is relatively small. They are typically found in small quantities in newborns. What does a high absolute value of nucleated red blood cells mean? Let's explore this topic.

1. What does a high absolute value of nucleated red blood cells mean?

If the absolute value of mononucleated cells is elevated, and you are experiencing no uncomfortable symptoms, there is probably nothing to worry about. The normal range of a particular indicator is merely a reference value. It's possible that your normal value falls outside the general population range, so you shouldn't be too nervous. However, if there is also an increase in white blood cells or lymphocytes, along with symptoms such as sore throat and nasal discharge, it may indicate an infection.

2. The appearance of nucleated red blood cells in adult peripheral blood is a pathological phenomenon.

This can be seen in:

Proliferative anemia: Most commonly seen in various types of anemia, such as acute hemorrhagic anemia, megaloblastic anemia, and severe hypochromic anemia. The appearance of late-stage and intermediate-stage erythroblasts is common. The presence of nucleated red blood cells in peripheral blood indicates significant and active proliferation of the erythroid series in the bone marrow;
Erythremia and erythroleukemia: Abnormal proliferation of immature erythroblasts in the bone marrow and their release into the blood, with proerythroblasts and early erythroblasts being the most common;
Extramedullary hematopoiesis: In bone marrow fibrosis, tissues such as the spleen, liver, and lymph nodes resume their embryonic hematopoietic function. Due to a lack of regulatory control over the release of blood cells, a large number of immature blood cells enter the peripheral blood. Erythroblasts at various stages of development can be observed, along with immature granulocytes and megakaryocytes;
Others: Such as bone marrow metastasis, severe hypoxia, etc.