What is the Price of Rocuronium Bromide Injection?

If you contract a disease in your daily life, it is important to seek timely and relevant treatment. In cases where the disease is more severe, surgical intervention may be necessary, which often requires the use of anesthetic medications. Rocuronium bromide injection is one such anesthetic adjuvant drug that is widely used in clinical settings. Many people are familiar with its application. So, what is the price of rocuronium bromide injection?

2. Efficacy and Function of Rocuronium Bromide Injection: Rocuronium bromide is an anesthetic adjuvant drug used primarily for tracheal intubation during routine induction of anesthesia, as well as to maintain intraoperative muscle relaxation.

3. Dosage and Administration of Rocuronium Bromide Injection: The dosage of rocuronium bromide should be individualized, similar to other muscle relaxants. When determining the dosage, it is important to consider factors such as the method of anesthesia, duration of surgery, sedation methods, duration of mechanical ventilation, interactions with other drugs being used, and the patient's condition. It is recommended to use appropriate muscle relaxation monitoring techniques to assess the depth and recovery of muscle relaxation.

Inhalation anesthetics can enhance the muscle-relaxing effect of rocuronium bromide. However, this synergistic effect is only clinically significant when the concentration of the inhalation anesthetic in the tissue reaches a level sufficient to produce the desired effect. Therefore, during prolonged surgical procedures (exceeding 1 hour) under inhalation anesthesia, the maintenance dose of rocuronium bromide should be reduced, the dosing interval extended, or the infusion rate slowed.

(Refer to "Drug Interactions") The following dosage recommendations for adult patients can be used as a general guide for tracheal intubation and various surgical muscle relaxation applications of varying durations. For surgical tracheal intubation, the standard intubation dose of rocuronium bromide during routine anesthesia is 0.6 mg per kilogram of body weight, which can provide satisfactory intubation conditions in almost all patients within 60 seconds. The recommended maintenance dose is 0.15 mg per kilogram of body weight, which may be appropriately reduced to 0.075-0.1 mg per kilogram in patients undergoing prolonged inhalation anesthesia. It is best to administer the maintenance dose when the height of muscle twitch has recovered to 25% of the control value or when there are 2-3 responses to a train-of-four stimulus.

For continuous infusion of rocuronium bromide, it is recommended to start with a bolus dose of 0.6 mg per kilogram of body weight via intravenous injection, followed by continuous infusion when muscle relaxation begins to recover. Adjust the infusion rate appropriately to maintain the height of muscle twitch at approximately 10% of the control value or to maintain 1-2 responses to a train-of-four stimulus. In adult patients under intravenous anesthesia, the infusion rate range for maintaining this level of muscle relaxation is 5-10 μg/kg/min, and under inhalation anesthesia, it is 5-6 μg/kg/min. Since the infusion requirements vary depending on the individual and the method of anesthesia, continuous monitoring of muscle relaxation is recommended during infusion.

Dosage for elderly patients, patients with liver and/or biliary disease, and/or renal failure: The standard dose for tracheal intubation during routine anesthesia in these patients is 0.6 mg/kg. Regardless of the anesthetic method used, the recommended maintenance dose for these patients is 0.075-0.1 mg/kg, with an infusion rate of 5-6 μg/kg/min. (See Continuous Infusion) Dosage for overweight and obese patients: When rocuronium bromide is administered to overweight and obese patients (defined as those with a body weight exceeding 30% or more of their ideal body weight), the dosage should be adjusted based on the composition of their muscle tissue and appropriately reduced.

Administration of Rocuronium Bromide: Rocuronium bromide is administered intravenously, either through intravenous injection or continuous infusion.

Administration in Children Under Halothane Anesthesia (Aged 1-14 Years):