Pantoprazole Enteric-Soluble Tablets: Usage Instructions and Information?

Pantoprazole Enteric-Coated Tablets, correctly known as Pantoprazole Sodium Enteric-Coated Tablets, is a drug used to inhibit gastric acid secretion, primarily for the treatment of active peptic ulcer (gastric and duodenal ulcer) and reflux esophagitis.

Pantoprazole Enteric-Coated Tablets is a proton pump inhibitor that works by specifically binding to the proton pumps on the gastric parietal cells, thereby inhibiting gastric acid secretion. It is indicated for the treatment of duodenal ulcer, gastric ulcer, moderate to severe reflux esophagitis, and also for the infection caused by Helicobacter pylori.

The dosage of Pantoprazole Enteric-Coated Tablets varies depending on the specific condition being treated, and should be prescribed by a doctor. For patients with renal impairment or elderly patients, the daily dose of Pantoprazole should generally not exceed 40 milligrams. For patients with severe liver impairment, the dose should be adjusted accordingly.

As an enteric-coated tablet, Pantoprazole should not be chewed or crushed. It should be taken one hour before breakfast in the morning with water. The main adverse reactions are related to the digestive system, such as upper abdominal pain, diarrhea, and constipation. Additionally, there may be central nervous system reactions like headache and dizziness, as well as skin reactions like allergic reactions, itching, and rash.

By specifically acting on the gastric parietal cells, Pantoprazole reduces the activity of the H+K+-ATP enzyme in these cells, thereby inhibiting gastric acid secretion. Compared to omeprazole and lansoprazole, Pantoprazole has a weaker inhibitory effect on cytochrome P450-dependent enzymes.

Occasionally, adverse reactions such as dizziness, insomnia, drowsiness, nausea, diarrhea, constipation, rash, and muscle pain may occur during clinical use.

In cases of overdose, symptoms such as arrhythmia, increased transaminase levels, altered renal function, and reduced granulocyte counts may occur.

1. Overdosage may result in arrhythmia, increased transaminase levels, altered renal function, and reduced granulocyte counts.

2. Do not chew the enteric-coated tablets.

3. When gastric ulcer is suspected, cancer should be excluded first as Pantoprazole may alleviate the symptoms, potentially delaying diagnosis.

4. The efficacy and safety of Pantoprazole in children have not been established.

5. Caution should be exercised in patients with hepatic or renal impairment.