What Should I Do If Helicobacter Pylori Treatment Fails?

Update Date: 2024-06-19 Source: Network

When it comes to Helicobacter pylori, everyone feels particularly familiar with it. Currently, Helicobacter pylori is the only bacterium that can parasitize in the stomach. When Helicobacter pylori infection occurs, it can cause damage to the stomach and have a certain impact on physical health. If Helicobacter pylori treatment fails, patients are advised to take remedial treatment. Generally, the four-drug combination therapy is chosen for treatment based on the specific condition of the patient.

1. What to do if Helicobacter pylori treatment fails

If Helicobacter pylori has not been eradicated after a course of formal treatment, a remedial treatment plan is recommended. The remedial treatment plan suggests a four-drug combination therapy for 14 days, and the choice of drugs should be based on the specific condition of the patient. If two consecutive eradication treatments fail, it is generally recommended to wait for more than half a year before considering eradication treatment again. It is advisable to go to a hospital that is capable of performing Helicobacter pylori drug sensitivity tests and select antibiotics based on the results of the tests.

2. Reasons for failure of Helicobacter pylori treatment

1. Poor patient compliance: Patient compliance directly determines the treatment outcome. Many patients give up medication after a few days of taking it because they cannot see significant results, which will result in all previous efforts being wasted.

2. Environmental factors: Hp is detected 4 weeks after discontinuation of medication. During these 4 weeks, recurrence or reinfection may have occurred, indicating that there is a significant population or family clustering of the infection.

3. Host genotype relationship: gastric PH value, host immune status, oral Hp colonization, gender, age, smoking, and alcohol consumption.

4. Development of bacterial resistance: Due to the abuse of antibiotics in recent years, Helicobacter pylori has increasingly developed resistance to antibiotics through chromosomal mutations, which is the main reason for the failure of Helicobacter pylori eradication. According to research, the resistance rates of Hp to antibiotics in China are 50%~100% for metronidazole, 0~40% for clarithromycin, and 0~2.7% for amoxicillin.

5. Irregular treatment: Failure to comply with the consensus opinions on the management of Helicobacter pylori issues at home and abroad can easily lead to the formation of spherical Hp and its resistant strains, which is an important cause of eradication failure.