How to Use and Dosage of Glipizide?
The main function of Glipizide is suitable for the treatment of type 2 diabetes. For diabetic patients, the method of taking Glipizide is mainly oral administration. The dosage of the drug will vary depending on the patient's condition, but the general recommended dose by doctors is between 20mg and 2.5mg. It is best to take it before breakfast or lunch. Generally, this drug must be taken before meals.
Glipizide is a second-generation sulfonylurea hypoglycemic agent with lipid-lowering and anticoagulant effects. Its hypoglycemic effect is rapid and strong, about 1000 times stronger than tolbutamide, and its efficacy is similar to glibenclamide. The mechanism of action is to stimulate the β-cells of the pancreas to increase insulin secretion, while also stimulating the α-cells of the pancreas to inhibit hyperglycemia secretion. Its mode of action is similar to chlorpropamide but with lower toxic and side effects and no teratogenic phenomenon. In addition, some people believe that Glipizide also inhibits the decomposition of liver glycogen, promotes the utilization and consumption of glucose in muscles, and may change the reactivity of insulin target tissues to insulin through extra-pancreatic effects, thus enhancing the effect of insulin. Therefore, some patients can effectively control their blood sugar for 24 hours with a single dose. Glipizide can correct the microvascular circulation disorders in early diabetes, reduce plasma triglyceride levels, accelerate the conversion of cholesterol to HDL in the body, and also reduce platelet aggregation and improve fibrinolysis and absorption capacity, thus inhibiting platelet aggregation, slowing the formation of thrombosis and endothelial injury in capillaries, and possibly having a certain preventive and therapeutic effect on microvascular lesions. Using controlled-release technology allows the drug to be released slowly, thus achieving a long-lasting hypoglycemic effect. The effect can last for 24 hours, reducing fasting blood sugar and postprandial blood sugar.
Dosage and Administration: Oral administration starts with 2.5mg, once before breakfast or before breakfast and lunch, or 1.25mg, three times a day, before meals. If necessary, the daily dosage can be increased by 2.5mg after 7 days. The general daily dose is 5-15mg, with a maximum daily dose not exceeding 20-30mg. The effect of 2.5mg of this product is equivalent to 0.5g of tolbutamide. Among sulfonylurea drugs, this product has the fastest gastrointestinal absorption, and the time of maximum effect is most consistent with the peak time of blood sugar increase after meals, thus reducing the chance of hypoglycemia before the next meal. It has a short half-life and a relatively small risk of causing severe and persistent hypoglycemia compared to other sulfonylurea drugs.
