What Are the Precautions for Administering Tetanus Immunoglobulin?

Tetanus immunoglobulin is made from high-potency plasma and serum collected after immunization with hepatitis B vaccine. Tetanus immunoglobulin can prevent and treat tetanus, especially suitable for people who are allergic to tetanus antitoxin. It is recommended to inject tetanus immunoglobulin according to medical advice. When injecting tetanus immunoglobulin, there are some precautions to be aware of. What are the precautions for injecting tetanus immunoglobulin?

1. While using this product for passive immunization, adsorbed tetanus vaccine can be used for active immunization, but the injection site and instruments should be separated.
2. The product should be a clear or slightly opalescent liquid, and may have trace precipitates, but they should dissipate immediately upon shaking. If there are insoluble precipitates or foreign matter, or if the vial is cracked or expired, it should not be used.
3. After opening the vial, the product should be injected in one administration and should not be used in multiple administrations.
4. Although this product is a human blood product that has undergone screening and virus inactivation treatment, it cannot completely eliminate the possibility of transmission of blood-borne diseases caused by unknown pathogens such as viruses.

Tetanus immunoglobulin is made from high-potency plasma or serum collected from healthy blood donors immunized with hepatitis B vaccine and then immunized with tetanus toxoid. It is mainly used for the prevention and treatment of tetanus, especially suitable for people who have allergic reactions to tetanus antitoxin. It is suitable for patients with unclear immunization history, serum allergy, wound infection for more than 24 hours, and those who still have no immunity after receiving tetanus toxoid. Tetanus immunoglobulin is made from the plasma of healthy individuals immunized with hepatitis B vaccine and then immunized with adsorbed tetanus vaccine, through extraction and virus inactivation. Human tetanus immunoglobulin belongs to artificial passive immunization, which produces an immediate immune effect after injection, but the duration is relatively short, with an immune duration of 2 weeks, generally not exceeding 3 weeks. There are generally no adverse reactions after injection. A very small number of people may have redness, swelling, and pain, which do not require special treatment and will resolve spontaneously.

Tetanus immunoglobulin is a high-potency tetanus antibody that can specifically neutralize tetanus toxin and play a role in passive immunization. Tetanus immunoglobulin is a homologous protein that can maintain its effective concentration in the body for 3-4 weeks. It can bind to tetanus toxin in the blood to the maximum extent. Repeated use will not increase sensitivity to the body and disrupt the presence of immunoglobulin in the blood. Therefore, it is effective for the prevention and treatment of tetanus.