What Are the Symptoms of Brugada Syndrome?
The main manifestations of Brugada syndrome are syncope or nocturnal near-death breathing, which belongs to an autosomal dominant genetic disease. It presents with various clinical manifestations and poses a significant risk to patients, sometimes even life-threatening, causing ventricular arrhythmias. The main cause of this disease is genetic factors.
1. Most clinical manifestations of Brugada syndrome are associated with life-threatening ventricular arrhythmias.
2. In up to 1/3 of patients, sudden cardiac death may be the initial manifestation of Brugada syndrome.
3. Patients may also manifest as syncope episodes and nocturnal near-death breathing.
4. Studies have shown that Brugada syndrome is autosomal dominant inheritance with multiple clinical phenotypes.
Brugada syndrome is a syndrome caused by abnormal ion channel function due to mutations in genes encoding myocardial ion channels. Genetic analysis can identify asymptomatic gene carriers of Brugada syndrome, allowing for clinical monitoring and early detection of clinical manifestations. Additionally, these gene carriers can undergo genetic counseling to understand the probability of passing the disease to the next generation. However, as only one gene has been linked to Brugada syndrome, there is insufficient data to predict clinical prognosis based on genetic defects alone. Currently, SCN5A gene mutations are not a marker of high risk for cardiac events, and genetic analysis does not contribute to risk stratification.
