"Why Does Thyroid-Stimulating Hormone Increase in Thyroid Cancer?"

Update Date: 2024-08-29 Source: Network

Elevated TSH Levels in Thyroid Cancer Patients

Elevated thyroid-stimulating hormone (TSH) levels in thyroid cancer patients may stem from excessive secretion of TSH receptor-stimulating hormone (TRH) by tumor cells or from hypothyroidism induced by treatments such as surgery or radiotherapy. It is recommended to seek medical attention promptly and undergo targeted treatment under medical guidance.

1. Causes:

If thyroid cancer patients undergo pathological examination revealing high levels of TRH secretion by tumor cells, this can trigger a feedback mechanism leading to increased TSH secretion by the pituitary gland, resulting in elevated TSH levels. Additionally, patients who have undergone total thyroidectomy or iodine-131 treatment may experience hypothyroidism, which can also cause TSH levels to rise.

2. Symptoms:

When TSH levels are elevated in thyroid cancer patients, they may exhibit no apparent clinical symptoms or may experience fatigue, cold intolerance, loss of appetite, and weight gain. Some patients may also present with low metabolic symptoms such as palpitations, excessive sweating, and hand tremors.

3. Treatment:

For patients with primary hyperthyroidism, medication such as methimazole tablets should be administered as prescribed by a physician. For those with secondary hypothyroidism, levothyroxine sodium tablets are typically prescribed. Regular follow-ups for blood tests, liver and kidney function, and other indicators are necessary, with medication dosages adjusted accordingly based on test results.

Apart from the aforementioned common scenarios, Hashimoto's disease concurrent with thyroid cancer can lead to the production of high levels of anti-thyroglobulin antibodies and anti-microsomal antibodies, affecting the pituitary's regulation of TSH, thereby causing TSH levels to rise. In such cases, active anti-inflammatory treatment is necessary, and medications like propylthiouracil can be prescribed to inhibit thyroid hormone synthesis.