What does a positive Nikolskys sign indicate?
What does a positive Nikolsky's sign indicate? Clinically, skin diseases with a positive Nikolsky's sign include: bullous epidermolysis bullosa drug eruption, staphylococcal scalded skin syndrome, pemphigus, epidermolysis bullosa, bullous pemphigus foliaceus, and other diseases.
What diseases are related to a positive Nikolsky's sign? Bullous epidermolysis bullosa drug eruption is a toxic side reaction caused by drugs. It is one of the most severe drug eruptions, with acute onset, rapid development, large damage area, and easy to be accompanied by multi-system harm. The rash initially appears on the face, neck, and chest, showing dark red, deep red, and iron-gray spots, which quickly spread to the whole body, developing into a systemic trend. Patches produce varying sizes of loose herpes and epidermal loosening, with a high mortality rate.
Staphylococcal scalded skin syndrome was once known as neonatal exfoliative dermatitis. This disease is characterized by acute onset, abundant erythema or focal redness throughout the body, skin tenderness, loose herpes or large areas of skin peeling, and large areas of peeling occur with a slight push on the skin, forming large-scale burns. It usually appears 1 to 5 weeks after birth and is less common in adults.
Pemphigus foliaceus is a severe, recurrent, and relatively serious chronic skin disease. In patients with pemphigus foliaceus, there exists an antigen against the Ca2-dependent intercellular adhesion molecule structure, desmoglein, in their bodies. Therefore, loose blisters appear on normal skin or mucous membranes, resulting in a positive Nikolsky's sign.
