Liver cancer is a clinically malignant disease, and it is impossible to accurately determine whether there is a problem with liver cancer solely based on symptoms. Therefore, it is still necessary to cooperate with professional examination and diagnosis to confirm. There are many diagnostic criteria for liver cancer, and they are not single diagnoses. Therefore, comprehensive consideration is generally made during diagnosis. For example, the numerical value of alpha-fetoprotein is one of the diagnostic basis. In addition to this, what are the other diagnostic criteria for liver cancer?
1. Comprehensive diagnosis includes clinical manifestations of liver cancer, plus radionuclide scanning, B-ultrasound, CT, hepatic artery angiography, X-ray diaphragmatic sign, enzymatic examination (such as alkaline phosphatase, γ-glutamyl transpeptidase), etc. There are three positive results that can exclude secondary liver cancer, which is also an aspect of the diagnostic criteria for liver cancer.
2. If there is no other evidence of liver cancer, alpha-fetoprotein convection method is positive or radioimmunoassay ≥500 micrograms/L for more than 1 month, or radioimmunoassay ≥200 micrograms/L for more than 2 months, and can exclude pregnancy, active liver disease (such as abnormal alanine aminotransferase, bilirubin, prothrombin time), gonadal embryonic tumors, etc. This is also a very important criterion in the diagnostic criteria for liver cancer.
3. Imaging examination requires positive AFP in the diagnostic criteria for liver cancer, but false positives should be excluded. If there is space-occupying lesion, it should also have the characteristics of liver cancer, which should be accurate. As a diagnostic criterion for liver cancer, it has been found in recent clinical work that the number of cases with negative AFP is increasing constantly, so it is very necessary to set this criterion. Due to the lack of a powerful diagnostic criterion for liver cancer such as positive AFP, more evidence should be sought in imaging diagnosis. Or add other diagnostic basis of liver cancer markers. However, the specificity of other liver cancer markers is not as good as AFP, so it is required that at least two reliable markers are positive. The purpose is naturally to increase the reliability of diagnosis, which is quite important in the diagnostic criteria for liver cancer.
