How to Treat Pregnant and Postpartum Women with Syphilis?

Update Date: 2024-05-16 Source: Network

Treatment Plan for Pregnant and Postpartum Women with Syphilis Infection

Pregnant and postpartum women infected with syphilis require timely treatment, typically through medication. Syphilis can be transmitted from mother to child, so infants also need to be examined and treated. However, it is not recommended that infants take medication orally; intravenous injection is preferred. Syphilis is a sexually transmitted disease with strong infectivity. During treatment, pregnant and postpartum women should avoid sexual activity and regularly monitor their condition. Specific treatment plans are outlined below.

I. Treatment Plan for Pregnant and Postpartum Women with Syphilis Infection

(1) Recommended Plan:

1. Procaine penicillin G, 800,000 units/day, intramuscular injection for 15 consecutive days;

2. Benzathine penicillin 2.4 million units, intramuscular injection into both buttocks, once weekly for a total of 3 times.

(2) Alternative Plan:

1. If penicillin is unavailable, ceftriaxone can be used at a dose of 1 gram/day, either intramuscularly or intravenously, for 10 consecutive days;

2. For patients allergic to penicillin, erythromycin can be used (tetracycline and doxycycline are contraindicated). Erythromycin should be taken orally at a dose of 500mg four times daily for 15 days.

II. Preventive Treatment Plan for Newborns Born to Mothers with Syphilis Infection

After birth, benzathine penicillin G should be administered at a dose of 50,000 units/kg body weight, injected intramuscularly into both buttocks.

III. Treatment Plan for Infants with Congenital Syphilis

(1) For infants with normal cerebrospinal fluid (CSF), benzathine penicillin G should be administered at a dose of 50,000 units/kg as a single injection into both buttocks.

(2) For infants with abnormal CSF, aqueous penicillin G should be administered intravenously at a dose of 50,000 units/kg divided into two doses daily for 10 to 14 consecutive days; alternatively, procaine penicillin G can be used at a dose of 50,000 units/kg daily, administered intramuscularly for 10 to 14 consecutive days. If CSF examination is not possible, treatment should be based on the assumption of abnormal CSF.